Calcitonin and chromogranin A localization in medullary carcinoma of the thyroid by immunoelectron microscopy.

Calcitonin receptor expression in medullary thyroid carcinoma

BACKGROUND Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin receptor (CTR), its seven-transmembrane G-protein coupled receptor, remains to be established in C-cells derived thyroid tumors. The aim of this work was to investigate CTR expression in MTC and to correlate such expression with clinicopathological features in order to...

Postoperative calcitonin study in medullary thyroid carcinoma.

Calcitonin (CT) is a sensitive marker for medullary thyroid carcinoma. Normalization of early postoperative CT level is a favorable prognostic factor. The aim of this study was to establish the prognostic value of CT-level kinetics by preoperative tumor stage and postoperative elimination rate. Blood serum from 22 medullary thyroid carcinoma (MTC) patients without remote metastases was assayed....

Serum calcitonin negative Medullary thyroid carcinoma

BACKGROUND Medullary thyroid carcinomas (MTC) constitute about 5 to 7% of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemical activity of MTC. In rare cases pre-operative serum calcitonin can be negative. CASE PRESENTATION We report on a 73-year-old female patient with a rare...

Biosynthesis of calcitonin gene-related peptide and calcitonin by a human medullary thyroid carcinoma cell line.

cDNA analyses predict that the human calcitonin gene encodes the two precursor proteins of calcitonin and calcitonin gene-related peptide (CGRP). The mRNAs for the putative precursors of these peptides are derived from alternative processing of the primary transcript of this gene. The 75 amino-terminal residues of each preprohormone are predicted to be identical. We have developed the TT human ...

Calcitonin Expression in the Metastatic Tissue of Medullary Thyroid Carcinoma